Human papillomaviruses target the double-stranded RNA protein kinase pathway.

The B56a Regulatory Subunit of Protein Phosphatase 2A Is a Target for Regulation by Double-Stranded RNA-Dependent Protein Kinase PKR

Inducible Expression of Double-Stranded RNA Reveals a Role for dFADD in the Regulation of the Antibacterial Response in Drosophila Adults

In Drosophila, the immune deficiency (Imd) pathway controls antibacterial peptide gene expression in the fat body in response to Gram-negative bacterial infection. The ultimate target of the Imd pathway is Relish, a transactivator related to mammalian P105 and P100 NF-kappaB precursors. Relish is processed in order to translocate to the nucleus, and this cleavage is dependent on both Dredd, an ...

THE EFFECT OF ENDURANCE TRAINING ON PROTEIN KINASE-B AND MECHANICAL TARGET OF RAPAMYCIN IN THE LEFT VENTRICLE OF THE HEART OF DIABETIC RATS INDUCED BY STREPTOZOTOCIN AND NICOTINAMIDE

Background: The pathway of insulin messengers is so important that diabetes can lead to disruption of this pathway. However, the aim of this study was to investigate the effect of 8 weeks of endurance training on protein Kinase-B (PKB or AKT) and mechanical target of rapamycin (mTOR) in the left ventricle of the heart of diabetic rats induced by streptozotocin and nicotinamide. Methods: In thi...

PKR, the double stranded RNA-dependent protein kinase as a critical target in Alzheimer's disease

Amyloid beta-peptide (Abeta) deposits and neurofibrillary tangles are key hallmarks in Alzheimer's disease (AD). Abeta stimulates many signal transducers involved in the neuronal death. However, many mechanisms remain to be elucidated because no definitive therapy of AD exists. Some studies have focused on the control of translation which involves eIF2 and eIF4E, main eukaryotic factors of init...

Double-stranded RNA activates a p38 MAPK-dependent cell survival program in biliary epithelia.

Double-stranded RNA (dsRNA) is produced during replicative viral infection or genotoxic stress. Thus knowledge of the cellular response to dsRNA is necessary to understand the effects of DNA damage or viral infection in biliary epithelia. We assessed the effect of dsRNA on biliary epithelial cell proliferation and apoptosis and the role of the stress-activated p38 MAPK signaling pathway in thes...